{
 "CCL26": {
  "target_pdb": "ccl26_target.pdb",
  "source": "1G2S (NMR, mature eotaxin-3, 71 aa)",
  "uniprot": "Q9Y258",
  "chain": "A",
  "design_hotspots_resi": [
   16,
   17,
   54,
   55,
   56
  ],
  "epitope_rationale": "N-loop (16,17) + C-terminal alpha-helix basic cluster (54,55,56); spans CCR3-binding N-loop face and the GAG-binding basic residues (PMID 35742962). A binder occluding this face blocks both receptor engagement and GAG-mediated gradient formation.",
  "binder_target": "neutralizing mini-binder / ligand trap"
 },
 "POSTN": {
  "target_pdb": "postn_target.pdb",
  "source": "5WT7 (NMR, FAS1 domain IV, 140 aa)",
  "uniprot": "Q15063",
  "region": "FAS1-IV (~UniProt 496-632)",
  "chain": "A",
  "design_hotspots_resi": [
   83,
   85,
   116,
   108
  ],
  "epitope_rationale": "Exposed patch on one face of the FAS1-IV domain (integrin-interaction unit). FAS1 domains mediate periostin-integrin (alpha-v) signaling driving remodeling; a binder here aims to block the matricellular/integrin function.",
  "binder_target": "neutralizing mini-binder / ligand trap"
 }
}