# Speaker notes / talking points

[Question] We asked which EoE genes are reproducible and druggable, across nine cohorts.
[Meta-signature] 622 genes pass FDR and fold-change; the canonical targets light up.
[Reproducible] Study-by-study the direction is consistent.
[LOCO] 399 of 567 survive dropping any single cohort — a robust core.
[Genetic] Seven sit at GWAS risk loci, separating cause from effector.
[Pathways] Interferon and type-2 up, barrier down.
[Landscape] Effect size versus priority gives the lead map.
[Druggability] All 20 leads are antibody-tractable.
[Next] Validate top five by IHC and design binders for CDH26 and ANO1.