{
 "NKG2D_MIC_blocker": {
  "complex_pdb": "1HYR",
  "target_to_block": "NKG2D\u2013MICA receptor-ligand engagement",
  "strategy": "MICA-decoy (soluble MICA \u03b11\u03b12 platform that sequesters NKG2D) OR de novo NKG2D binder covering the MICA footprint",
  "MICA_interface_residues": [
   "TRP14",
   "ASP15",
   "GLY16",
   "SER17",
   "VAL18",
   "GLN19",
   "SER20",
   "ARG38",
   "ARG64",
   "ASP65",
   "LYS71",
   "ASP72",
   "ARG74",
   "MET75",
   "ALA78",
   "HIS79",
   "LYS81",
   "PHE145",
   "ASP149",
   "ALA150",
   "MET151",
   "THR153",
   "THR155",
   "HIS156",
   "HIS158",
   "ALA159",
   "ALA162",
   "ASP163",
   "GLN166"
  ],
  "NKG2D_interface_residues": [
   "LYS147",
   "LYS150",
   "SER151",
   "TYR152",
   "THR180",
   "ILE181",
   "ILE182",
   "GLU183",
   "MET184",
   "GLN185",
   "LYS186",
   "LEU191",
   "ALA193",
   "SER194",
   "SER195",
   "LYS197",
   "TYR199",
   "GLU201",
   "THR205",
   "PRO206",
   "ASN207",
   "THR208"
  ],
  "n_mica_if": 29,
  "n_nkg2d_if": 22
 },
 "IL15_blocker": {
  "complex_pdb": "4GS7",
  "target_to_block": "IL-15 signaling via IL-2R\u03b2 + \u03b3c (spare IL-15R\u03b1 trans-presentation face)",
  "strategy": "Mini-binder to the IL-15 \u03b2/\u03b3c signaling epitope (neutralize like AMG-714 but gut-restricted format)",
  "IL15_signaling_epitope": [
   "ASN1",
   "VAL3",
   "ASN4",
   "ILE6",
   "SER7",
   "ASP8",
   "GLU28",
   "ASP30",
   "VAL31",
   "HIS32",
   "PRO33",
   "ASP61",
   "THR62",
   "GLU64",
   "ASN65",
   "LEU66",
   "ILE68",
   "LEU69",
   "ASN72",
   "VAL104",
   "HIS105",
   "VAL107",
   "GLN108",
   "MET109",
   "ILE111",
   "ASN112"
  ],
  "IL15_beta_face": [
   "ASN1",
   "VAL3",
   "ASN4",
   "ILE6",
   "SER7",
   "ASP8",
   "ASP61",
   "THR62",
   "GLU64",
   "ASN65",
   "LEU66",
   "ILE68",
   "LEU69",
   "ASN72"
  ],
  "IL15_gc_face": [
   "VAL3",
   "ILE6",
   "GLU28",
   "ASP30",
   "VAL31",
   "HIS32",
   "PRO33",
   "VAL104",
   "HIS105",
   "VAL107",
   "GLN108",
   "MET109",
   "ILE111",
   "ASN112"
  ],
  "IL15_alpha_face_AVOID": [
   "HIS20",
   "ASP22",
   "ALA23",
   "THR24",
   "LEU25",
   "TYR26",
   "LEU45",
   "GLU46",
   "GLN48",
   "VAL49",
   "LEU52",
   "GLU53",
   "GLU87",
   "CYS88",
   "GLU89",
   "GLU90",
   "GLU93"
  ],
  "n_signaling_epitope": 26
 }
}